Episode 48
Arteries, LDL and MOTS-c: the Full Story
The long version: how LDL sticks, why the deep fat around your organs acts like an inflammation factory, and what trials measured with retatrutide and MOTS-c, a peptide your mitochondria make themselves.
Now playing · Episode 48
Arteries, LDL and MOTS-c: the Full Story
Transcript
- Right now, inside your arteries, something is sticking.
- Tiny particles of fat, called LDL,
- drift through your blood every day. Most of them keep
- moving. Some get stuck on the artery walls.
- They stay. More follow. A layer forms. The wall thickens.
- The opening narrows. Over the years,
- the artery becomes a pipe with less and less room to flow.
- One day a piece breaks off. It blocks the
- flow downstream. That is what doctors call a heart attack.
- Most people never feel it building.
- They find out from a single blood test. So why is fat
- sticking in the first place?
- The answer is upstream. The deep visceral fat around your
- organs is acting like an inflammation
- factory. It pumps out signals that make your liver produce
- more LDL than it should. Your mitochondria,
- the tiny engines that handle fat in your liver and muscle
- cells, slow down. The system stops keeping
- up. More LDL gets pumped into your blood. Less of it gets
- burned off. The arteries pay the price.
- Two peptides can help on both sides of this problem. Rita
- Trutide is a triple pathway peptide built to
- shrink visceral fat from the source. It quiets appetite at
- the brain, improves insulin sensitivity,
- and signals the liver to burn its own stored fat instead of
- pumping out more LDL. In trials,
- Retatrutide has lowered triglycerides, dropped LDL, and
- pulled cholesterol numbers in the right direction.
- MOTS-c is a peptide your mitochondria make themselves. It
- tells the cells to switch fuel back toward fat
- burning and clean up the cholesterol cycle from the inside.
- Together they hit the problem from two
- angles. Retatrutide reduces the fat factory upstream. MOT
- SC restores the engines that process what is left.