Peptide Research Explained, by Pepi

All episodes

• BPC-157 and TB-500: a Footballer's Knee Story

  A weekend footballer with a bad knee, and the two peptides his story names: BPC-157, studied for blood vessel growth in damaged tissue, and TB-500, studied for moving tissue cells to the site.

  0:40
• The Fastest One in the Ring: an Athlete's Comeback

  He used to be the fastest one in the ring; then his old shorts stopped fitting. A short story about what researchers are studying in peptide signalling for tissue and training.

  0:23
• Have You Heard of the Spark Stack?

  The drive that fades in your 30s is a master pulse going quiet upstream. Spark pairs kisspeptin and CJC-1295: what each is studied for, and why the two are stacked.

  0:59
• Parkinson's Early Signs: Semax and NAD+ Research

  Ten million people live with Parkinson's. Dopamine, BDNF, and what researchers are measuring with neuroprotective peptides. Not a remedy; a look at the science.

  2:01
• Semax Memory Research: the Thumb-Sized Region

  Inside the brain is a thumb-sized region where every memory lives: the hippocampus. Amyloid plaques, BDNF, and what neuro-research peptides are being studied for.

  1:43
• NAD+ and the Artery Wall: Every Heartbeat Is a Hammer

  Every beat is a hammer on the artery wall, and one day the wall no longer bounces back. The endothelium, the 13 mm figure researchers cite, and what NAD+ studies have measured.

  2:03
• One in Three Livers: Fatty Liver Peptide Research

  A healthy liver is deep red and firm; one in three looks pale and fat-laden instead. The hepatocyte mechanism, and what tesamorelin and retatrutide research has measured.

  2:08
• MOTS-c and LDL: What Sticks Inside Your Arteries

  Right now, inside your arteries, LDL particles are drifting and some are sticking. This explainer covers the lipid mechanism and what retatrutide and MOTS-c research has measured.

  1:58
• Blood Pressure Peptides: Pepi on Tight Arteries

  When arteries stay tight, blood cannot move the way it should. Pepi shows a peptide signal reaching the vessel walls, the idea behind cardiovascular peptide research.

  0:38
• Appetite Peptides: Pepi on Where Hunger Lives

  Pepi follows a peptide to the part of the brain where hunger lives and shows how quieting that signal changes what the body asks for. A short on appetite signalling research.

  0:35
• GLP-3 Retatrutide: Three Signals in One Peptide

  Meet GLP-3, a character for the triple-agonist retatrutide: one signal for hunger at the brain, one for how cells answer insulin, and one for how the body uses stored fat.

  0:29
• Retatrutide vs Belly Fat: the Metabolic Arena

  A title bout in the metabolic arena: belly fat in the yellow corner, and in the green corner a triple-action peptide, the design behind retatrutide. What visceral-fat research measures, told as a fight.

  0:53
• Retatrutide Peptide: the Molecule With Three Doors

  Retatrutide is a triple-agonist research peptide that signals through three receptors at once. This explainer covers the mechanism trials have measured and why it remains research-only.

  0:55
• Energy and Focus Peptides: Mark's Story

  Mark was the dad his kids ran to, until the elevator replaced the stairs and his back started talking in the mornings. His story follows peptide signals studied for energy, focus and sleep.

  1:47
• Mitochondria and Peptides: Pepi on Cellular Energy

  Pepi goes inside the cell to the mitochondria, the engines that dim with age, and shows how a peptide signal travels through the bloodstream to reach them. A short on cellular energy research.

  0:36
• The Transformation: One Body, Two Timelines

  A before-and-after told as a short film with no narration. What peptide research is measuring about body composition, and why the story is about signals, not shortcuts.

  0:45
• Unboxing a Pre-Filled Peptide Pen (16 Seconds)

  Sixteen seconds of what arrives: a sealed pre-filled pen, wipes, tips, everything measured. No mixing, no reconstitution.

  0:15
• Meet Pepi: How a Peptide Finds Its Target

  Meet Pepi, the peptide. Thirty seconds on how a peptide travels the bloodstream, locks onto a receptor, and signals the cell, the mechanism every explainer on this channel builds on.

  0:30
• PNC-27: the Peptide That Targets the HDM2 Marker

  PNC-27 is a 32-amino-acid research peptide built from two fused pieces and studied for its binding to the HDM2 surface marker. What cell-line research has measured, and what has not been shown.

  0:34
• Thymosin Alpha-1 Peptide: What Your Thymus Makes

  Thymosin alpha-1 is a 28-amino-acid fragment of a protein made by the thymus, the small organ behind your breastbone that trains immune cells. What immune research has measured.

  1:21
• Kisspeptin-10: the 10-Amino-Acid Master Signal

  Kisspeptin-10 is the shortest active piece of your body's own kisspeptin, the upstream signal for the reproductive hormone axis. What human and animal studies have measured about it.

  1:17
• MOTS-c Peptide: Encoded in Your Mitochondria

  MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA and studied for its link to AMPK, the cell's fuel switch. A plain-language look at the metabolic research.

  1:14
• Selank Peptide: Built From Tuftsin, a Molecule You Make

  Selank is a seven-amino-acid peptide derived from tuftsin, a natural immune molecule. This explainer covers how it is being studied in anxiety and attention research and what remains unmeasured.

  1:17
• Tesamorelin Peptide: the Long-Acting GHRH Analogue

  Tesamorelin is a 44-amino-acid GHRH analogue studied for sustained growth-hormone signalling. What visceral-fat and metabolic research has measured, and what is still open.

  1:13
• CJC-1295 Peptide: a Synthetic GHRH Explained

  CJC-1295 is a 30-amino-acid synthetic version of growth-hormone-releasing hormone (GHRH). A plain-language look at the receptor it targets and what studies have measured about pulse frequency.

  0:40
• Ipamorelin Peptide: 5 Amino Acids, One Ghrelin Receptor

  Ipamorelin is a five-amino-acid peptide studied for how it binds the ghrelin receptor on the pituitary. This explainer walks through the growth-hormone signalling researchers have measured.

  1:22
• TB-500 Peptide: the Thymosin Beta-4 Fragment

  TB-500 is a synthetic fragment of thymosin beta-4, a protein your body already makes. What tissue and cell-migration studies have measured, in plain language.

  1:15
• Semax Peptide: the 7-Amino-Acid Fragment of ACTH

  Semax is a seven-amino-acid peptide engineered from a fragment of ACTH. This explainer covers how it is being studied in cognition and attention research, and where the evidence runs out.

  1:02
• NAD+: Why You Have Half at 50 What You Had at 20

  NAD+ is the coenzyme every cell uses to turn food into energy, and levels are reported to fall by roughly half between 20 and 50. What researchers are studying about mitochondria and NAD+.

  0:16
• GHK-Cu Peptide: 3 Amino Acids, 4,000 Genes

  GHK-Cu is a copper peptide just three amino acids long that researchers report modulates the expression of thousands of genes. A plain-language look at what skin and tissue studies have actually measured.

  1:03
• BPC-157: the 15-Amino-Acid Peptide From Your Stomach

  BPC-157 is a 15-amino-acid chain your stomach lining produces on its own. This explainer looks at what published studies have measured in tissue and gut models, and what remains unknown.

  0:50
• What Is a Peptide? Your Body Makes Thousands a Day

  What is a peptide? A short chain of amino acids that your body already makes by the thousand every day. Pepi walks through how one finds its receptor, like a key into a lock, and what researchers are still working out.

  1:41