Episode 52
Kisspeptin for Men: Low T and the HPG Axis
The HPG axis runs from brain to pituitary to testes, and its testosterone signal weakens from the 30s. The short covers kisspeptin, the upstream signal of that axis, and CJC-1295, a long-acting growth hormone secretagogue.

Now playing · Episode 52
Kisspeptin for Men: Low T and the HPG Axis
Transcript
- When did you stop saying yes? To the workout? To the late night? To her? To yourself? It crept in.
- Maybe it was 40. Maybe earlier. The energy that powered everything started going somewhere else.
- The drive softened. The morning thing became occasional. The afternoon yawn became permanent.
- You're not sad. You're not depressed. You're just less you. This isn't aging. It's a hormone signal
- that quietly went offline. Your body runs on a feedback loop called the HPG axis. Your brain
- tells your pituitary. Your pituitary tells your testes. Your testes produce testosterone. That
- hormone runs muscle, drive, mood, focus and libido. It's the spark behind everything that makes you feel
- like you. Starting in your 30s, that signal weakens. By 40, you're producing half of what you used to.
- By 50, less. You're not sick. You're just running on a fraction of the fuel you were built for.
- There's a way to restart the signal. Two peptides, working in tandem. kisspeptin. The master signal.
- It's the same molecule your brain uses naturally to kick off the HPG axis. When you supplement with it,
- you reactivate the conversation between your hypothalamus, your pituitary, and your testes.
- Testosterone production restarts. Libido returns. Morning energy comes back. Mood stabilizes. The
- fire that ran your 20s starts firing again. CJC-1295. The amplifier. A long-acting growth hormone signal
- that pulses for hours after a single dose. While kisspeptin restores your testosterone,
- CJC-1295 brings back the second hormonal signal that builds muscle, sharpens recovery, and supports the
- energy that testosterone needs to actually express itself. Sleep deepens. Body composition shifts.
- Workouts produce results again. Fire the spark. Fan the flame. Together, the man who showed up to
- everything starts showing up again. Libido returns. Morning energy holds. Workouts build muscle.