Episode 54
Tirzepatide Peptide: Two Receptors, GLP-1 and GIP
Tirzepatide acts on two receptors at once: GLP-1, which carries the fullness signal from gut to brain, and GIP, which affects how fat tissue handles stored energy. Pepi explains why the two signals are studied together.
Now playing · Episode 54
Tirzepatide Peptide: Two Receptors, GLP-1 and GIP
Transcript
- Two doors, not one.
- Most weight loss molecules knock on a single door.
- Your body answers for a while, then stops listening and progress stalls.
- Hi, this is Pepi, and this is tirzepatide.
- It opens two doors at the same time.
- Door one is called GLP-1.
- It carries the message from your gut up to your brain that you have had enough.
- Door two is called GIP.
- It changes how your fat tissue handles the energy you already have in storage.
- On their own, each of these signals fades.
- Together, they hold each other up,
- so appetite and blood sugar stop pulling against each other and start moving in step.
- Here is what people feel.
- Cravings get quiet.
- Energy stays level through the afternoon,
- because your cells are responding to insulin again.
- And stored fat finally gets drawn on as fuel, instead of sitting in reserve.
- Many people pair it with a growth hormone peptide,
- so what they lose is fat and not muscle.