Episode 11
MOTS-c Peptide: Encoded in Your Mitochondria
MOTS-c is a 16-amino-acid peptide encoded in mitochondrial DNA and studied for its link to AMPK, the cell's fuel switch. A plain-language look at the metabolic research.

Now playing · Episode 11
MOTS-c Peptide: Encoded in Your Mitochondria
Transcript
- Hi, Peppy here, and this is MOTSC, a tiny peptide, just 16
- amino acids long.
- But this one is different from every other peptide, because
- it does not come from your
- regular DNA.
- It comes from your mitochondrial DNA, the ancient code
- inside the power plants of every
- cell.
- Here's what makes it special.
- MOTSC is your body's own metabolic signal.
- It tells your cells to switch their fuel, to stop storing
- fat and start burning it.
- How?
- By activating an enzyme called AMPK, the master fuel switch
- inside every cell.
- When MOTSC flips this switch on, glucose flows into your
- cells faster.
- Fat is oxidized for energy, and brand new mitochondria are
- built.
- Here's what people feel.
- The afternoon crash fades.
- Energy stays steady all day.
- Workouts feel lighter.
- Recovery comes faster.
- Stubborn body fat, especially around the midsection,
- finally starts moving.
- And the brain fog of getting older lifts.
- Mental clarity returns.
- Many people pair it with Tessamorelin to amplify the
- metabolic effect and lock in real fat loss.